Lorenzo Lucca, David Neres and Billy Gilmour step in for injury-hit Napoli, joining Kevin De Bruyne for the trip to Giovanni Simeone’s Torino.
It kicks off at the Stadio Olimpico Grande Torino at 17.00 UK time (16.00 GMT).
The Partenopei are joint top of the Serie A table with Roma, but the break for international duty only further added to their injury worries.
Stanislav Lobotka, Amir Rrahmani, Romelu Lukaku and Nikita Contini are out of action, while Matteo Politano and Alessandro Buongiorno are not fully fit either.
It means Gilmour takes over the midfield reins with De Bruyne, while Neres gets the nod out wide, but Scott McTominay and Rasmus Hojlund are not even on the bench.
According to Sky Sport Italia, McTominay has an ankle issue, while Hojlund feels a strain in his calf muscle.
Instead, Lucca and in a more advanced role Leonardo Spinazzola get the nod for a 4-3-3 formation.
Torino are deeply unpredictable under new coach Marco Baroni, as their only victory of the Serie A season was 1-0 away to joint leaders Roma.
However, they suffered heavy losses to Inter and Atalanta, also falling at Parma before a chaotic 3-3 draw at Lazio.
Injuries are a big problem here too, with Zakaria Aboukhlal, Tino Anjorin, Ivan Ilic, Zanos Savva and Perr Schuurs out, while Ardian Ismajli is not at 100 per cent either.
Giovanni Simeone gets to face his former club, having left Napoli over the summer to seek more regular playing time.
Italy Under-21 international Cesare Casadei and ex-Inter midfielder Kristjan Asllani bring quality to the midfield.
Torino vs. Napoli official line-ups
Torino: Israel; Tameze, Coco, Maripan; Pedersen, Casadei, Asllani, Vlasic, Nkounkou; Adams, Simeone
Napoli: Milinkovic-Savic; Di Lorenzo, Beukema, Juan Jesus, Olivera; Anguissa, Gilmour, De Bruyne; Neres, Lucca, Spinazzola
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